ParkinsonCanadaV1, Main, Exploration, bibRecord, 000B69

A brain network response to sham surgery

Identifieur interne : 000B69 ( Main/Exploration ); précédent : 000B68; suivant : 000B70

A brain network response to sham surgery

Auteurs : Mariya V. Cherkasova ; A. Jon Stoessl

Source :

The Journal of Clinical Investigation [ 0021-9738 ] ; 2014.

RBID : PMC:4109557

English descriptors

KwdEn :
- Brain (metabolism), Brain (surgery), Female, Humans, Male, Parkinson Disease (metabolism), Parkinson Disease (surgery), Placebo Effect.
MESH :
- metabolism : Brain, Parkinson Disease.
- surgery : Brain, Parkinson Disease.
- Female, Humans, Male, Placebo Effect.

Abstract

Evaluation of potential therapies for neurological disease has been challenging due to beneficial responses in patients receiving the sham/placebo treatment. Placebo effects are especially prominent in Parkinson’s disease (PD), which has become a useful model for studying the neurobiology of placebo responses. In this issue of the JCI, Ko and colleagues identify a neural circuit associated with the placebo response in a PD patient cohort. The observed placebo effect–associated pattern involved metabolic activity increases that corresponded with long-term motor improvements after sham surgery. Presurgery activity in this network was inversely related to sham response, suggesting that this network has potential for identifying sham responders and thus reducing placebo-related variance in surgical trials.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109557

DOI: 10.1172/JCI77193
PubMed: 25036701
PubMed Central: 4109557

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Evaluation of potential therapies for neurological disease has been challenging due to beneficial responses in patients receiving the sham/placebo treatment. Placebo effects are especially prominent in Parkinson’s disease (PD), which has become a useful model for studying the neurobiology of placebo responses. In this issue of the <italic>JCI</italic>
, Ko and colleagues identify a neural circuit associated with the placebo response in a PD patient cohort. The observed placebo effect–associated pattern involved metabolic activity increases that corresponded with long-term motor improvements after sham surgery. Presurgery activity in this network was inversely related to sham response, suggesting that this network has potential for identifying sham responders and thus reducing placebo-related variance in surgical trials.</p>
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La maladie de Parkinson au Canada (serveur d'exploration)

A brain network response to sham surgery

A brain network response to sham surgery

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.